alzheimersdisease
New research provides evidence that using two common Alzheimer’s disease medications together can significantly increase patients’ chances of surviving beyond five years from diagnosis. The study, published in Communications Medicine, suggests that this combined treatment could extend the lives of approximately 303,000 people with Alzheimer’s disease in the United States. Alzheimer’s disease is the most common form of dementia, characterized by progressive memory loss, cognitive decline, and behavioral changes. It affects over 50 million people worldwide and is a leading cause of death. Alzhei...
PsyPost (UK)
Researchers from the National University of Singapore have made a groundbreaking discovery about the role of a little-known protein in the brain, which could revolutionize the treatment of Alzheimer’s disease and other neurological conditions. Their study, published inCell Research, reveals that the protein Mfsd7c plays a critical role in managing choline levels in the brain, challenging previous assumptions and offering new therapeutic possibilities. Alzheimer’s disease and other neurological disorders present significant health challenges, particularly as the global population ages. Current ...
PsyPost (UK)
In a recent study published in the journal Alzheimer’s & Dementia, researchers have discovered that the connectivity between the locus coeruleus and the medial temporal lobe can be an early indicator of Alzheimer’s disease-related brain atrophy and cognitive decline. They found that lower connectivity between these brain regions during a novelty task was associated with faster atrophy in regions typically affected by Alzheimer’s disease. The motivation behind the new study stemmed from the need to understand the early mechanisms of Alzheimer’s disease, which is characterized by the accumulatio...
PsyPost (UK)
A new study sheds light the potential mechanism linking a diet high in saturated fats to Alzheimer’s disease. Researchers have identified specific changes in small RNA molecules, known as microRNAs, that act as markers and regulators of the disease, shedding light on how dietary habits can influence the onset of neurodegenerative conditions. The findings were published in the journal Nutrients. “The results of this study are a step forward in our understanding of this disease and may explain the relationship between obesity, type 2 diabetes and the onset of Alzheimer’s. The findings also offer...
PsyPost (UK)
Recent scientific advancements have shown that a lesser-known compound from the cannabis plant, cannabinol (CBN), may hold promise for treating neurological disorders such as Alzheimer’s and Parkinson’s disease. Researchers at the Salk Institute discovered that not only does CBN protect brain cells from age-related damage, but its chemically modified versions could be even more effective. These findings, detailed in the journal Redox Biology, suggest a new frontier in the treatment of traumatic brain injuries and other neurodegenerative diseases. With the prevalence of neurological disorders r...
PsyPost (UK)
A review of the available scientific literature indicates that alcohol consumption and exposure to stress are associated with an increased risk of Alzheimer’s disease and related dementias. However, the specific mechanisms responsible for this association remain unknown. The paper was published in Neurobiology of Stress. Alzheimer’s disease is a progressive neurological disorder that primarily affects elderly individuals, leading to memory loss, cognitive decline, and personality changes. It is caused by the buildup of abnormal proteins in and around brain cells – amyloid plaques and tau tangl...
PsyPost (UK)
In a new study published in Cell Reports00456-X), researchers have developed a sophisticated systems biology approach that combines artificial intelligence (AI), genetics, and multi-omics analyses to explore how metabolites produced by gut bacteria might influence Alzheimer’s disease. The study identifies specific receptors in the human body that these metabolites interact with, potentially opening new avenues for therapeutic intervention. This significant finding could lead to the development of novel drugs that target these interactions, offering hope for treating or even preventing Alzheime...
PsyPost (UK)
Alzheimer’s disease, a major cause of dementia, currently affects approximately 50 million people worldwide, a number expected to triple by 2050. A recent study published in the Annals of Neurology explores the relationship between stressful life events and the risk of developing Alzheimer’s disease, focusing on how the timing and nature of these stressors might influence disease onset. The study finds that not all stressful events are equally impactful, with midlife or childhood stressors showing a stronger association with Alzheimer’s disease risk factors compared to stress accumulated over ...
PsyPost (UK)
Have you ever wondered if the minor forgetfulness you experience is a normal part of aging, or perhaps an early sign of something more serious, like Alzheimer’s disease? A new study published in npj Digital Medicine offers hope for early detection of Alzheimer’s disease through memory self-tests conducted on smartphones. Researchers have developed a dedicated app that can accurately identify mild cognitive impairment, a precursor to Alzheimer’s. This research, a collaborative effort by scientists from the German Center for Neurodegenerative Diseases (DZNE), the Otto-von-Guericke University Mag...
PsyPost (UK)
In a study conducted by Weill Cornell Medicine scientists, a novel human neuron model has been developed that simulates the spread of tau protein aggregates in the brain. This phenomenon is a key driver behind cognitive decline observed in Alzheimer’s disease and frontotemporal dementia. The study, published in Cell00306-4), helps to identify potential targets for drug development that could block the spread of tau aggregates. Tau aggregates are clumps of misfolded tau proteins that accumulate inside the neurons of the brain, disrupting their normal function and leading to cell death. These ag...
PsyPost (UK)
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