alzheimersdisease
Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. This might sound like science fiction, but innovative new research is making it a potential reality. Scientists have discovered that when mice with Alzheimer’s inhaled menthol, their cognitive abilities improved. This unexpected finding highlights a potential new avenue for treating this debilitating condition. Alzheimer’s disease is a serious neurodegenerative disorder that gets worse over time. It is characterised by changes in the brain that result in loss of neurons and connection...
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New research provides evidence that using two common Alzheimer’s disease medications together can significantly increase patients’ chances of surviving beyond five years from diagnosis. The study, published in Communications Medicine, suggests that this combined treatment could extend the lives of approximately 303,000 people with Alzheimer’s disease in the United States. Alzheimer’s disease is the most common form of dementia, characterized by progressive memory loss, cognitive decline, and behavioral changes. It affects over 50 million people worldwide and is a leading cause of death. Alzhei...
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A groundbreaking study published in Acta Neuropathologica has identified a genetic variant that can reduce the risk of developing Alzheimer’s disease by up to 70%. This variant appears to help in removing toxic amyloid from the brain through the blood-brain barrier, highlighting the significant role that blood vessels in the brain may play in Alzheimer’s disease. These findings could pave the way for new therapeutic approaches to prevent or treat Alzheimer’s disease. “Alzheimer’s disease may get started with amyloid deposits in the brain, but the disease manifestations are the result of change...
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Researchers from the National University of Singapore have made a groundbreaking discovery about the role of a little-known protein in the brain, which could revolutionize the treatment of Alzheimer’s disease and other neurological conditions. Their study, published inCell Research, reveals that the protein Mfsd7c plays a critical role in managing choline levels in the brain, challenging previous assumptions and offering new therapeutic possibilities. Alzheimer’s disease and other neurological disorders present significant health challenges, particularly as the global population ages. Current ...
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In a recent study published in the journal Alzheimer’s & Dementia, researchers have discovered that the connectivity between the locus coeruleus and the medial temporal lobe can be an early indicator of Alzheimer’s disease-related brain atrophy and cognitive decline. They found that lower connectivity between these brain regions during a novelty task was associated with faster atrophy in regions typically affected by Alzheimer’s disease. The motivation behind the new study stemmed from the need to understand the early mechanisms of Alzheimer’s disease, which is characterized by the accumulatio...
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A new study sheds light the potential mechanism linking a diet high in saturated fats to Alzheimer’s disease. Researchers have identified specific changes in small RNA molecules, known as microRNAs, that act as markers and regulators of the disease, shedding light on how dietary habits can influence the onset of neurodegenerative conditions. The findings were published in the journal Nutrients. “The results of this study are a step forward in our understanding of this disease and may explain the relationship between obesity, type 2 diabetes and the onset of Alzheimer’s. The findings also offer...
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Researchers have discovered that individuals who live to be 100 years old and remain cognitively healthy possess genetic variations that may protect against Alzheimer’s disease. These “protective alleles” are significantly more prevalent among centenarians compared to Alzheimer’s patients and even middle-aged individuals without the disease. This finding could pave the way for new approaches in preventing and treating Alzheimer’s, particularly by focusing on enhancing these protective genetic mechanisms. The new findings have been published in the journal Alzheimer’s & Dementia. Alzheimer’s di...
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A review of the available scientific literature indicates that alcohol consumption and exposure to stress are associated with an increased risk of Alzheimer’s disease and related dementias. However, the specific mechanisms responsible for this association remain unknown. The paper was published in Neurobiology of Stress. Alzheimer’s disease is a progressive neurological disorder that primarily affects elderly individuals, leading to memory loss, cognitive decline, and personality changes. It is caused by the buildup of abnormal proteins in and around brain cells – amyloid plaques and tau tangl...
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In a new study published in Cell Reports00456-X), researchers have developed a sophisticated systems biology approach that combines artificial intelligence (AI), genetics, and multi-omics analyses to explore how metabolites produced by gut bacteria might influence Alzheimer’s disease. The study identifies specific receptors in the human body that these metabolites interact with, potentially opening new avenues for therapeutic intervention. This significant finding could lead to the development of novel drugs that target these interactions, offering hope for treating or even preventing Alzheime...
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Alzheimer’s disease, a major cause of dementia, currently affects approximately 50 million people worldwide, a number expected to triple by 2050. A recent study published in the Annals of Neurology explores the relationship between stressful life events and the risk of developing Alzheimer’s disease, focusing on how the timing and nature of these stressors might influence disease onset. The study finds that not all stressful events are equally impactful, with midlife or childhood stressors showing a stronger association with Alzheimer’s disease risk factors compared to stress accumulated over ...
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