psilocybin
The U.S. Drug Enforcement Agency announced in late April 2024 that it plans to ease federal restrictions on cannabis, reclassifying it from a Schedule I drug to the less restricted Schedule III, which includes drugs such as Tylenol with codeine, testosterone and other anabolic steroids. This historic shift signals an acknowledgment of the promising medicinal value of cannabis. The move comes in tandem with growing interest in the use of psilocybin, the active component in magic mushrooms, for treatment of depression, chronic pain and other conditions. In 2018 and 2019, the U.S. Food and Drug A...
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A recent case study published in Clinical Case Reports describes the journey of a 41-year-old woman who turned to psilocybin and MDMA to manage her debilitating post-COVID symptoms. The paper raises the intriguing possibility, which is far from certain, that psychedelic substances might help alleviate the psychological and cognitive symptoms associated with Long-COVID. Long-COVID, also known as post-acute sequelae of SARS-CoV-2 infection, encompasses a range of symptoms that persist well beyond the initial recovery from COVID-19. These symptoms can include fatigue, cognitive impairment, anxiet...
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Recent research published in the journal Molecular Psychiatry has provided new insights into the potential therapeutic effects of psilocybin, a psychedelic compound, on cognitive flexibility and weight maintenance in a rat model of anorexia. The study found that psilocybin not only helps maintain body weight in female rats subjected to conditions mimicking anorexia nervosa but also enhances cognitive flexibility, particularly in adapting to changes in reward contingencies. Psilocybin is a naturally occurring psychedelic compound found in certain species of mushrooms, commonly known as “magic m...
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A recent pilot study published in the Journal of Psychedelic Studies has found preliminary evidence that psilocybin, when administered in a group retreat setting, can enhance psychological flexibility. The findings suggest that changes in psychological flexibility may play a crucial role in the therapeutic benefits of psilocybin experiences. Psilocybin is a naturally occurring psychedelic compound found in over 200 species of mushrooms, known colloquially as “magic mushrooms.” When ingested, psilocybin is converted into psilocin in the body, which then influences serotonin receptors in the bra...
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Recent scientific advancements have shed light on the potential synergistic effects of meditation and psychedelic substances. A study published in Scientific Reports reveals how psilocybin, a psychedelic compound, when combined with open monitoring meditation may enhance the depth of insightfulness in experienced meditators. This enhancement appears to be mediated by changes in the brain’s organizational patterns. Open monitoring meditation is a type of meditation that emphasizes the broad, non-reactive awareness of the content of experience from moment to moment. Unlike focused attention medi...
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In recent years, interest in psychedelic-assisted therapy has grown due to its potential to treat various psychological disorders such as depression, anxiety, and post-traumatic stress disorder. However, a new study published in the Journal of Psychedelic Studies raises important concerns. It suggests that while there may be benefits, there are also significant risks. The study focuses on the negative effects reported by therapists who facilitate such treatments, highlighting that the impacts of psilocybin are not universally beneficial and can vary widely from one individual to another. Psilo...
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Scientists have recently discovered that psilocybin, the active ingredient in “magic mushrooms,” can significantly reduce chronic pain in rats. Notably, this pain relief was related to pain from touch, but not pain from heat. The study was published in Current Biology01374-X). Psychedelic drugs have recently gained attention for their potential to treat various psychiatric disorders. Psilocybin, in particular, has been the subject of research for its therapeutic effects on treatment-resistant depression as well as alcohol and tobacco abuse. Led by Nicholas Kolbman, researchers from the Univers...
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Scientists have started to investigate whether a compound found in magic mushrooms, psilocybin, could play a role in combating the effects of diabetes. According to their preliminary research, published in the journal Genes, psilocybin might help prevent the loss of critical insulin-producing cells in the pancreas. Psilocybin is a naturally occurring psychedelic compound found in certain species of mushrooms. In recent years, its therapeutic potential has begun to be recognized, particularly for mental health conditions. The rationale for this study, however, stems from psilocybin’s interactio...
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A recent study examined the role of patient expectations in influencing the outcomes of treatments with psilocybin, a psychedelic substance, compared to escitalopram, a widely prescribed antidepressant. Contrary to what some might expect, the study did not find a significant link between patients’ expectations and their actual responses to psilocybin therapy. However, the study also indicates that individuals who are more suggestible might experience a greater benefit from this treatment. The findings have been published in the journal Psychological Medicine. Depression’s staggering global imp...
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In recent years, the scientific community has turned its attention back to the potential of psychedelics as therapeutic agents, with psilocybin, a naturally occurring substance found in certain mushrooms, at the forefront of this research. A new study published in the journal Molecular Psychiatry suggests possible benefits of using psilocybin-containing mushroom extract over its chemically synthesized counterpart for the treatment of psychiatric disorders such as depression, PTSD, obsessive-compulsive disorders, and anxiety. “My colleagues and I are very interested in the potential of psychede...
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