San Diego Padres pitcher Yu Darvish took his seventh loss after giving up an equal season-worst seven runs over 4-1/3 innings in an 8-4 loss to the Pittsburgh Pirates on Monday.
Darvish (7-7) allowed eight hits, including four home runs, two of them by Carlos Santana, leaving the mound with a 7-1 deficit at Petco Park.
Santana hit a pair of two-run homers, putting the Pirates ahead 3-1 in the third and making it 7-1 two innings later.
The Pirates' Liover Peguero also went deep off Darvish for a two-run shot in the fourth and finished with three RBIs.
The veteran right-hander walked three and struck out three in an 85-pitch outing.
At Target Field in Minneapolis, Kenta Maeda held the Seattle Mariners to one run with eight strikeouts over 6-1/3 innings as his Minnesota Twins walked off with a 4-3 win in 10 innings for their fourth consecutive victory.
