Yu Darvish allowed four runs over seven innings to take the loss as the San Diego Padres fell 4-1 against the Baltimore Orioles on Monday.
Darvish (8-8), who gave up eight hits and a walk, struck out six at Petco Park and set the record for most MLB strikeouts by a Japanese player at 1,919, going one above Hideo Nomo.
Ryan O'Hearn pulled a 1-2 sweeper with no out in the second off Darvish for a solo home run as the Orioles scored with their first hit of the game.
Darvish allowed two hits and a walk to load the bases in the fifth with one out, and Gunnar Henderson's opposite-field double to the left corner cleared the bases for a 4-0 lead.
The right-hander tied and then set the Japanese record in the sixth when he fanned both Ryan Mountcastle and Ramon Urias with third-pitch fastballs.
Garrett Cooper's solo shot off Grayson Rodriguez (3-3) in the home half was the only run for the Padres.
At Globe Life Field in Arlington, Texas, Los Angeles Angels two-way star Shohei Ohtani went hitless in three at-bats in a 12-0 loss to the Texas Rangers.
