Conference League champions West Ham United roared into the Europa League quarter-finals after thumping Germany's Freiburg 5-0, with AC Milan, Marseille and Benfica also progressing on Thursday.
The Londoners have proved themselves to be a major European force in recent years, having also reached the Europa League semi-finals two seasons ago.
Freiburg, hoping to reach the last eight of European competition for the first time, won last week's first leg 1-0 at home but Lucas Paquetá brought West Ham level after just 9 minutes when he powered in from close range.
Forward Jarrod Bowen then celebrated his latest England call-up with a superb goal just after the half hour at the London Stadium before Aaron Cresswell and a Mohammed Kudus double sealed a 5-1 aggregate victory.
Milan flew into the last eight of a competition they have never won with a 3-1 win at 10-man Slavia Prague, giving the Rossoneri a 7-3 aggregate success.
US winger Christian Pulisic and English midfielder Ruben Loftus-Cheek netted within two minutes of each other in the first half as the Czechs paid a heavy price for Tomáš Holeš being sent off after just 20 minutes for a dangerous foul.
Rafael Leão made it three on half-time before Matěj Jurásek's consolation.
Villarreal won 3-1 but it was not enough to overturn Marseille's 4-0 victory from last week as the French side edged through in Spain.
Benfica knocked out Rangers 3-2 on aggregate after a 1-0 win in Glasgow thanks to Rafa Silva's 66th-minute goal.
Four second legs are taking place later, including Bundesliga leaders Bayer Leverkusen hosting Azerbaijan's Qarabag with their tie at 2-2.
