Ollie Watkins netted again to help Aston Villa in to the Conference League last eight following a 4-0 victory over Ajax Amsterdam on Thursday.
The England striker, named in the latest Three Lions squad for friendlies later this month, headed in a first-half corner for his third of the competition and 22nd of the season.
Leon Bailey extended Villa's lead in the second period before Ajax's Sivert Mannsverk was dismissed. John Duran and Moussa Diaby then added the gloss as the 1982 European champions eliminated the Dutch giants.
Fiorentina nudged into the quarter-finals of Europe's third-tier competition after a 1-1 home draw with Maccabi Haifa secured a 5-4 aggregate victory.
Antonín Barák headed home in the second half in Florence and Anan Khalaili's goal two minutes from time came too late for the Israelis.
Lille coasted through after a 1-1 home draw against Sturm Graz following a 3-0 win in the first leg in Austria.
Fenerbahce went through 3-1 on aggregate despite suffering a 1-0 defeat in Istanbul to Saint Gilloise.
PAOK Salonika beat Dinamo Zagreb 5-1 on the night and 5-3 overall in an impressive turnaround in Greece, Konstantinos Koulierakis' goal on 72 minutes making the difference before Andrija Zivković's penalty.
Club Brugge secured a 3-0 victory at home to Molde to win 4-2 overall.
Viktoria Plzen against Servette went to penalties after no goals in either leg, but the Czechs eventually prevailed 3-1 in the shoot-out.
The draw for April's open quarter-finals is on Friday.