Coach Xavi Hernandez will leave Barcelona at the end of the season, the Spanish club said.
"Barcelona president Joan Laporta has informed Xavi Hernández that he will not be continuing as first team coach in the 2024-25 season," a statement read.
Just a month ago, Xavi had reversed a decision to step down this summer after two and a half years in charge.
"During the course of the next few days, FC Barcelona will be making an announcement regarding the new first team structure," the club said.
According to several media reports, former Bayern Munich and Germany coach is the top favourite to take the job. The Mundo Deportivo newspaper said on Friday that Flick is to be announced as Barcelona coach on Monday.
According to the report, Flick and Barcelona sporting director Deco had a decisive phone call last Wednesday. However, some details, such as the length of the contract, are yet to be clarified.
Xavi said in January he would step down after the season, but changed his mind in April by signing until 2025. His dismissal comes after his remarks on Barcelona's financial situation and a not competitive squad, which have angered the club leadership.
Flick, 59, was reportedly a candidate from the beginning. He was lately linked with a return to Bayern and with Chelsea but is said to have turned the English side down because Barcelona were his priority.
Flick became Bayern coach in autumn 2019, first on an interim basis, and led them to an astonishing seven titles: two Bundesligas, German Cup, German Super Cup, Champions League, European Super Cup and Club World Cup.
The run to the Champions League title included an 8-2 thrashing of Barcelona in the quarter-finals.
He succeeded Joachim Löw as Germany coach in 2021 but that spell was not successful as Germany went out in the group stage of the 2022 World Cup and Flick had to go last autumn after further poor results.