Vicious circle of depression and memory loss found among over-50s

New research has shed light on the degree to which healthy memory is tied to mental health. Klaus-Dietmar Gabbert/dpa

Depression can contribute to memory loss and vice-versa, according to researchers who studied around 8,200 British people over two decades.

The team found "linear change in depressive symptoms" to have "contributed to accelerated memory loss" among the participating group, which was made up of people aged 50 and up and with a mean age of 64.

But not only does depression affect memory, the reverse appears also true, the researchers reported, in a paper published by the American Medical Association.

"A steeper change in memory was also reciprocally associated with a more rapid change in depressive symptoms over time," according to the UK-US team, which included scientists and doctors from University College London, University of Rochester Medical Center and Brighton and Sussex Medical School.

"Psychological mood and memory performance are intrinsically associated," the researchers explained, pointing out that although cognitive dysfunction had previously been linked to depression, "the directionality of this association" was unclear.

Participants were examined every second year between 2002 and 2019, using measurements such as memory and verbal fluency tests as well as a depressive symptoms evaluation format provided by the Center for Epidemiologic Studies.

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