ketamine
In recent years, ketamine, once known primarily as an anesthetic, has emerged as a groundbreaking treatment for depression, offering rapid relief to many patients who have not responded to traditional antidepressants. A study published in Translational Psychiatry has shed light on the underlying mechanisms of ketamine’s fast-acting antidepressant effects, revealing a critical role played by the opioid system in the brain. Despite its known role in blocking certain receptors in the brain associated with glutamate—a neurotransmitter linked to mood regulation—ketamine’s interaction with the brain...
PsyPost
In recent years, ketamine, once known primarily as an anesthetic, has emerged as a groundbreaking treatment for depression, offering rapid relief to many patients who have not responded to traditional antidepressants. A study published in Translational Psychiatry has shed light on the underlying mechanisms of ketamine’s fast-acting antidepressant effects, revealing a critical role played by the opioid system in the brain. Despite its known role in blocking certain receptors in the brain associated with glutamate—a neurotransmitter linked to mood regulation—ketamine’s interaction with the brain...
PsyPost (CA)
Scientists at Northwestern University have made significant strides in understanding how ketamine, a drug known for its rapid antidepressant effects, operates on a neural level. This research not only sheds light on the mechanisms behind ketamine’s dual-action — providing both immediate and long-term relief from depression — but also paves the way for the development of new, safer antidepressant medications. The findings were recently published in Cellular and Molecular Life Sciences. Ketamine, originally known for its use as an anesthetic, has emerged as a significant player in the treatment ...
PsyPost (UK)
Scientists at Northwestern University have made significant strides in understanding how ketamine, a drug known for its rapid antidepressant effects, operates on a neural level. This research not only sheds light on the mechanisms behind ketamine’s dual-action — providing both immediate and long-term relief from depression — but also paves the way for the development of new, safer antidepressant medications. The findings were recently published in Cellular and Molecular Life Sciences. Ketamine, originally known for its use as an anesthetic, has emerged as a significant player in the treatment ...
PsyPost
Scientists at Northwestern University have made significant strides in understanding how ketamine, a drug known for its rapid antidepressant effects, operates on a neural level. This research not only sheds light on the mechanisms behind ketamine’s dual-action — providing both immediate and long-term relief from depression — but also paves the way for the development of new, safer antidepressant medications. The findings were recently published in Cellular and Molecular Life Sciences. Ketamine, originally known for its use as an anesthetic, has emerged as a significant player in the treatment ...
PsyPost (CA)
The first-line pharmacological treatment for major depressive disorder (MDD) are antidepressant drugs known as selective serotonin re-uptake inhibitors (SSRIs). But a significant proportion of people don’t respond to these drugs. Given that major depression is a global mental health problem that is on the increase, it is important to find novel pharmacological treatments for those who do not respond to the current ones. But to do that, we need to understand exactly how the drugs work – which we currently don’t. MDD is a debilitating and distressing mental health disorder, trapping sufferers in...
PsyPost
A recent study provides additional evidence that ketamine may be effective in treating severe forms of depression. Conducted across four major U.S. medical institutions, the study found that ketamine infusions led to significant improvements in depressive symptoms, including suicidality, in individuals who had not responded to conventional treatments. The research is part of a larger project that seeks to uncover blood-based biomarkers of treatment response. The new findings were recently published in the Journal of Affective Disorders. The Driving Force Behind the StudyMajor depressive disord...
PsyPost
The drug ketamine can reduce the symptoms of post-traumatic stress disorder, or PTSD, and symptoms of depression in patients as early as a day after injection. That is the key finding of my team’s new meta-analysis, just published in the journal Annals of Pharmacotherapy. Ketamine is an anesthetic that is sometimes used as a substance of abuse but is increasingly being explored as a treatment for a range of mental health conditions. We analyzed six randomized controlled trials representing 259 patients with moderate to severe PTSD. In all trials, about half were injected with ketamine. The res...
PsyPost
Scientists have discovered that rapid-acting antidepressants, such as ketamine, psilocybin, and scopolamine, are capable of altering negative mood biases, a common symptom in depressive disorders, in rodent models. This finding opens new avenues for understanding and treating major depressive disorder, a condition affecting millions worldwide. The research was published in Science Translational Medicine. Major Depressive Disorder is a common but serious mental health condition that negatively affects how a person feels, thinks, and acts. It is characterized by persistent feelings of sadness an...
PsyPost
New research published in Translational Psychiatry sheds light on how ketamine, a drug known for its rapid antidepressant effects, specifically alters brain activity in people with treatment-resistant depression. This detailed investigation into the brain’s anterior cingulate cortex reveals that ketamine’s influence on different regions of this area correlates with notable improvements in depressive and anhedonic symptoms. Ketamine, initially known as an anesthetic, has recently gained attention in the mental health community for its rapid antidepressant effects, particularly in individuals wh...
PsyPost
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